A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens.

ABSTRACT:

Background

Pax6 is a transcription factor that is required for induction, growth, and maintenance of the lens; however, few direct target genes of Pax6 are known.

Results

In this report, we describe the results of a cDNA microarray analysis of lens transcripts from transgenic mice over-expressing Pax6 in lens fibre cells in order to narrow the field of potential direct Pax6 target genes. This study revealed that the transcript levels were significantly altered for 508 of the 9700 genes analysed, including five genes encoding the cell adhesion molecules beta1-integrin, JAM1, L1 CAM, NCAM-140 and neogenin. Notably, comparisons between the genes differentially expressed in Pax6 heterozygous and Pax6 over-expressing lenses identified 13 common genes, including paralemmin, GDIbet

SUBMITTER: Chauhan BK 

PROVIDER: S-EPMC2080869 | biostudies-literature | 2002 Dec

REPOSITORIES: biostudies-literature