Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.

ABSTRACT:

Background

The human herpes simplex virus (HSV) host cell factor HCF-1 is a transcriptional coregulator that associates with both histone methyl- and acetyltransferases, and a histone deacetylase and regulates cell proliferation and division. In HSV-infected cells, HCF-1 associates with the viral protein VP16 to promote formation of a multiprotein-DNA transcriptional activator complex. The ability of HCF proteins to stabilize this VP16-induced complex has been conserved in diverse animal species including Drosophila melanogaster and Caenorhabditis elegans suggesting that VP16 targets a conserved cellular function of HCF-1.

Methodology/principal findings

To investigate the role of HCF proteins in animal development, we have characterized the effects of loss of the HCF-1 homol

SUBMITTER: Lee S 

PROVIDER: S-EPMC2082077 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature