Transforming growth factor: beta signaling is essential for limb regeneration in axolotls.

ABSTRACT: Axolotls (urodele amphibians) have the unique ability, among vertebrates, to perfectly regenerate many parts of their body including limbs, tail, jaw and spinal cord following injury or amputation. The axolotl limb is the most widely used structure as an experimental model to study tissue regeneration. The process is well characterized, requiring multiple cellular and molecular mechanisms. The preparation phase represents the first part of the regeneration process which includes wound healing, cellular migration, dedifferentiation and proliferation. The redevelopment phase represents the second part when dedifferentiated cells stop proliferating and redifferentiate to give rise to all missing structures. In the axolotl, when a limb is amputated, the missing or wounded part is regenerated p

SUBMITTER: Levesque M 

PROVIDER: S-EPMC2082079 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature