Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families.

ABSTRACT:

Background

Atopic dermatitis develops as a result of complex interactions between several genetic and environmental factors. To date, 4 genome-wide linkage studies of atopic dermatitis have been performed in Caucasian populations, however, similar studies have not been done in Asian populations. The aim of this study was to identify chromosome regions linked to atopic dermatitis in a Japanese population.

Methods

We used a high-density, single nucleotide polymorphism genotyping assay, the Illumina BeadArray Linkage Mapping Panel (version 4) comprising 5,861 single nucleotide polymorphisms, to perform a genome-wide linkage analysis of 77 Japanese families with 111 affected sib-pairs with atopic dermatitis.

Results

We found suggestive evidence for linkage with 15q21 (LOD

SUBMITTER: Enomoto H 

PROVIDER: S-EPMC2082241 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature