Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers.

ABSTRACT: The long-term health outcome of prenatal exposure to arsenic has been associated with increased mortality in human populations. In this study, the extent to which maternal arsenic exposure impacts gene expression in the newborn was addressed. We monitored gene expression profiles in a population of newborns whose mothers experienced varying levels of arsenic exposure during pregnancy. Through the application of machine learning-based two-class prediction algorithms, we identified expression signatures from babies born to arsenic-unexposed and -exposed mothers that were highly predictive of prenatal arsenic exposure in a subsequent test population. Furthermore, 11 transcripts were identified that captured the maximal predictive capacity to classify prenatal arsenic exposure. Network analysi

SUBMITTER: Fry RC 

PROVIDER: S-EPMC2082467 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature