Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues.

ABSTRACT: The Drosophila sex determination hierarchy controls all aspects of somatic sexual differentiation, including sex-specific differences in adult morphology and behavior. To gain insight into the molecular-genetic specification of reproductive behaviors and physiology, we identified genes expressed in the adult head and central nervous system that are regulated downstream of sex-specific transcription factors encoded by doublesex (dsx) and fruitless (fru). We used a microarray approach and identified 54 genes regulated downstream of dsx. Furthermore, based on these expression studies we identified new modes of DSX-regulated gene expression. We also identified 90 and 26 genes regulated in the adult head and central nervous system tissues, respectively, downstream of the sex-specific transcript

SUBMITTER: Goldman TD 

PROVIDER: S-EPMC2082469 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature