Ontology highlight
ABSTRACT:
SUBMITTER: Keats JJ
PROVIDER: S-EPMC2083698 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Cancer cell 20070801 2
Activation of NF-kappaB has been noted in many tumor types, however only rarely has this been linked to an underlying genetic mutation. An integrated analysis of high-density oligonucleotide array CGH and gene expression profiling data from 155 multiple myeloma samples identified a promiscuous array of abnormalities contributing to the dysregulation of NF-kappaB in approximately 20% of patients. We report mutations in ten genes causing the inactivation of TRAF2, TRAF3, CYLD, cIAP1/cIAP2 and acti ...[more]