Between order and disorder in protein structures: analysis of "dual personality" fragments in proteins.

ABSTRACT: In their natural environment, three-dimensional structures of proteins undergo significant fluctuations and are often partially or completely disordered. This phenomenon recently became the focus of much attention, as many proteins, especially from higher organisms, were shown to contain large intrinsically disordered regions. Such disordered regions may become ordered only under very specific circumstances, if at all, and can be recognized by specific amino acid composition and sequence signatures. Here, we suggest that the balance between order and disorder is much more subtle in that many regions are very close to the order/disorder boundary. Specifically, analysis of redundant sets of experimental models of protein structures, where emphasis is put on comparison of structures of identi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2084070 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature