Eph receptor and ephrin signaling in developing and adult brain of the honeybee (Apis mellifera).

ABSTRACT: Roles for Eph receptor tyrosine kinase and ephrin signaling in vertebrate brain development are well established. Their involvement in the modulation of mammalian synaptic structure and physiology is also emerging. However, less is known of their effects on brain development and their function in adult invertebrate nervous systems. Here, we report on the characterization of Eph receptor and ephrin orthologs in the honeybee, Apis mellifera (Am), and their role in learning and memory. In situ hybridization for mRNA expression showed a uniform distribution of expression of both genes across the developing pupal and adult brain. However, in situ labeling with Fc fusion proteins indicated that the AmEphR and Amephrin proteins were differentially localized to cell body regions in the mushroom bo

SUBMITTER: Vidovic M 

PROVIDER: S-EPMC2084376 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature