Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women.

ABSTRACT:

Background

Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2).

Methods

Three polymorphisms of the ESR2 gene, and their associated haplotypes, were evaluated in 296 white women from the Women's Health Study and 566 white men from the Physicians' Health Study who developed CVD [myocardial infarction (MI) or ischemic stroke], each matched 1:1 to a member of the cohort study who remained free from CVD. Blood samples and cardiovascular risk information were collected at baseline.

Results

Women, but not men, who developed CVD or MI, but not ischemic stroke, were more likely to have the rs1271572 polymorp

SUBMITTER: Rexrode KM 

PROVIDER: S-EPMC2085372 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature