Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins.

ABSTRACT: Signal transduction pathways are typically controlled by protein-protein interactions, which are mediated by specific modular domains. One hypothetical use of such interaction domains is to generate new signaling pathways and networks during eukaryotic evolution, through the joining of distinct binding modules in novel combinations. In this manner, new polypeptides may be formed that make innovative connections among preexisting proteins. Adaptor proteins are specialized signaling molecules composed exclusively of interaction domains, that frequently link activated cell surface receptors to their intracellular targets. Receptor tyrosine kinases (RTKs) recruit adaptors, such as Grb2 and ShcA, that activate signaling pathways involved in growth and survival, whereas death receptors bind adap

SUBMITTER: Howard PL 

PROVIDER: S-EPMC208746 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature