Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice.

ABSTRACT: MHC typing for human hematopoietic cell transplantation (HCT) from unrelated donors is currently performed by using a combination of serologic and molecular techniques. It has been determined that allelic differences in human MHC molecules, revealed by nucleotide sequencing but not by serologic typing, substantially influence graft rejection and graft-versus-host disease, two serious complications of clinical HCT. We studied transplantation of purified hematopoietic stem cells in a series of mouse strains that were matched at the MHC but had different background genes, and we observed striking differences in engraftment resistance and graft-versus-host disease severity, both factors depending on the donor-recipient strain combination. The individual mouse lines studied here were establishe

SUBMITTER: Cao TM 

PROVIDER: S-EPMC208799 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature