Avoidance of protein fold disruption in natural virus recombinants.

ABSTRACT: With the development of reliable recombination detection tools and an increasing number of available genome sequences, many studies have reported evidence of recombination in a wide range of virus genera. Recombination is apparently a major mechanism in virus evolution, allowing viruses to evolve more quickly by providing immediate direct access to many more areas of a sequence space than are accessible by mutation alone. Recombination has been widely described amongst the insect-transmitted plant viruses in the genus Begomovirus (family Geminiviridae), with potential recombination hot- and cold-spots also having been identified. Nevertheless, because very little is understood about either the biochemical predispositions of different genomic regions to recombine or what makes some recombin

SUBMITTER: Lefeuvre P 

PROVIDER: S-EPMC2092379 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature