Gene-centric characteristics of genome-wide association studies.

ABSTRACT:

Background

The high-throughput genotyping chips have contributed greatly to genome-wide association (GWA) studies to identify novel disease susceptibility single nucleotide polymorphisms (SNPs). The high-density chips are designed using two different SNP selection approaches, the direct gene-centric approach, and the indirect quasi-random SNPs or linkage disequilibrium (LD)-based tagSNPs approaches. Although all these approaches can provide high genome coverage and ascertain variants in genes, it is not clear to which extent these approaches could capture the common genic variants. It is also important to characterize and compare the differences between these approaches.

Methodology/principal findings

In our study, by using both the Phase II HapMap data and the disease varia

SUBMITTER: Dong C 

PROVIDER: S-EPMC2092383 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature