Measurement of physiological recovery from exacerbation of chronic obstructive pulmonary disease using within-breath forced oscillometry.

ABSTRACT:

Background

Within-breath reactance from forced oscillometry estimates resistance via its inspiratory component (X(rs,insp)) and flow limitation via its expiratory component (X(rs,exp)).

Aim

To assess whether reactance can detect recovery from an exacerbation of chronic obstructive pulmonary disease (COPD).

Method

39 subjects with a COPD exacerbation were assessed on three occasions over 6 weeks using post-bronchodilator forced oscillometry, arterial blood gases, spirometry including inspiratory capacity, symptoms and health-related quality of life (HRQOL).

Results

Significant improvements were seen in all spirometric variables except the ratio of forced expiratory volume in 1 s (FEV(1)) to vital capacity, ranging in mean (SEM) size from 11.0 (2.2)% predicted fo

SUBMITTER: Johnson MK 

PROVIDER: S-EPMC2092458 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature