Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests.

ABSTRACT:

Background

Lung clearance index (LCI), a measure of ventilation inhomogeneity derived from the multiple-breath inert gas washout (MBW) technique, has been shown to detect abnormal lung function more readily than spirometry in preschool children with cystic fibrosis, but whether this holds true during infancy is unknown.

Objectives

To compare the extent to which parameters derived from the MBW and the raised lung volume rapid thoraco-abdominal compression (RVRTC) techniques identify diminished airway function in infants with cystic fibrosis when compared with healthy controls.

Methods

Measurements were performed during quiet sleep, with the tidal breathing MBW technique being performed before the forced expiratory manoeuvres.

Results

Measurements were obtained i

SUBMITTER: Lum S 

PROVIDER: S-EPMC2092467 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature