Oxidative stress in the external intercostal muscles of patients with obstructive sleep apnoea.

ABSTRACT:

Background

The external intercostal muscles are chronically exposed to increased inspiratory loading and to continuous hypoxia-reoxygenation cycles in patients with obstructive sleep apnoea syndrome (OSAS). It was therefore hypothesised that oxidative stress levels would be increased in these muscles, and that treatment with continuous positive airway pressure (CPAP) would modify the oxidative stress levels and improve muscle dysfunction.

Methods

A case-control study and a case-case study were conducted on the external intercostal muscles of 12 patients with severe OSAS (before and after 6 months of treatment with CPAP) and 6 control subjects. Reactive carbonyl groups, malondialdehyde (MDA)-protein and hydroxynonenal (HNE)-protein adducts, antioxidant enzyme levels, 3-nitrot

SUBMITTER: Barreiro E 

PROVIDER: S-EPMC2094293 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature