Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging.

ABSTRACT:

Background

Long-lived strains of dwarf mice carry mutations that suppress growth hormone (GH) and insulin-like growth factor I (IGF-I) signaling. The downstream effects of these endocrine abnormalities, however, are not well understood and it is unclear how these processes interact with aging mechanisms. This study presents a comparative analysis of microarray experiments that have measured hepatic gene expression levels in long-lived strains carrying one of four mutations (Prop1(df/df), Pit1(dw/dw), Ghrhr(lit/lit), GHR-KO) and describes how the effects of these mutations relate to one another at the transcriptional level. Points of overlap with the effects of calorie restriction (CR), CR mimetic compounds, low fat diets, gender dimorphism and aging were also examined.

Results</

SUBMITTER: Swindell WR 

PROVIDER: S-EPMC2094713 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature