The association between gastro-oesophageal reflux disease and asthma: a systematic review.

ABSTRACT:

Background and aims

Gastro-oesophageal reflux disease (GORD) has been linked to a number of extra-esophageal symptoms and disorders, primarily in the respiratory tract. This systematic review aimed to provide an estimate of the strength and direction of the association between GORD and asthma.

Methods

Studies that assessed the prevalence or incidence of GORD in individuals with asthma, or of asthma in individuals with GORD, were identified in Medline and EMBASE via a systematic search strategy.

Results

Twenty-eight studies met the selection criteria. The sample size weighted average prevalence of GORD symptoms in asthma patients was 59.2%, whereas in controls it was 38.1%. In patients with asthma, the average prevalence of abnormal oesophageal pH, oesophagitis and hia

SUBMITTER: Havemann BD 

PROVIDER: S-EPMC2095717 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature