Prediction and preliminary validation of oncogene regulation by miRNAs.

ABSTRACT:

Background

MicroRNAs (miRNAs) are one of the most abundant groups of regulatory genes in multicellular organisms, playing important roles in many fundamental cellular processes. More than four hundred miRNAs have been identified in humans and the deregulation of miRNA expression has been also shown in many cancers. Despite the postulated involvement of miRNAs in tumourigenesis, there are only a few examples where an oncogene or a tumour suppressor has been identified as a miRNA target.

Results

Here, we present an in silico analysis of potential miRNA- oncogene interactions. Moreover, we have tested the validity of two possible interactions of miRNAs with genes related to cancer. We present evidence for the down-regulation of c-MYC, one of the most potent and frequently dereg

SUBMITTER: Koscianska E 

PROVIDER: S-EPMC2096627 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature