Different patterns of Ca²⁺ signals are induced by low compared to high concentrations of P2Y agonists in microglia.

ABSTRACT: Brain-resident macrophages (microglia) are key cellular elements in the preservation of tissue integrity. On the other hand, they can also contribute to the development of pathological events by causing an extensive and inappropriate inflammatory response. A growing number of reports indicate the involvement of nucleotides in the control of microglial functions. With this study on P2Y receptors in rat microglia, we want to contribute to the definition of their expression profile and to the characterisation of their signalling mechanisms leading to Ca²⁺ movements. Endogenous nucleotides, when applied at a concentration of 100 muM, elicited robust Ca²⁺ transients, thanks to a panel of metabotropic receptors comprising mainly P2Y₂, P2Y₆ and P2Y₁₂ subtypes. The involvement of P2Y₁₂ receptors i

SUBMITTER: Visentin S 

PROVIDER: S-EPMC2096653 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature