Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.

ABSTRACT: During cell division all chromosomes must be segregated accurately to each daughter cell. Errors in this process give rise to aneuploidy, which leads to birth defects and is implicated in cancer progression. The spindle checkpoint is a surveillance mechanism that ensures high fidelity of chromosome segregation by inhibiting anaphase until all kinetochores have established bipolar attachments to spindle microtubules. Bub1 kinase is a core component of the spindle checkpoint, and cells lacking Bub1 fail to arrest in response to microtubule drugs and precociously segregate their DNA. The mitotic role(s) of Bub1 kinase activity remain elusive, and it is controversial whether this C-terminal domain of Bub1p is required for spindle checkpoint arrest. Here we make a detailed analysis of budding y

SUBMITTER: Fernius J 

PROVIDER: S-EPMC2098806 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature