Androgen-induced masculinization in rainbow trout results in a marked dysregulation of early gonadal gene expression profiles.

ABSTRACT:

Background

Fish gonadal sex differentiation is affected by sex steroids treatments providing an efficient strategy to control the sexual phenotype of fish for aquaculture purposes. However, the biological effects of such treatments are poorly understood. The aim of this study was to identify the main effects of an androgen masculinizing treatment (11beta-hydroxyandrostenedione, 11betaOHDelta4, 10 mg/kg of food for 3 months) on gonadal gene expression profiles of an all-female genetic population of trout. To characterize the most important molecular features of this process, we used a large scale gene expression profiling approach using rainbow trout DNA microarrays combined with a detailed gene ontology (GO) analysis.

Results

2,474 genes were characterized as up-regulated or

SUBMITTER: Baron D 

PROVIDER: S-EPMC2099445 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature