Computational analysis of the relationship between allergenicity and digestibility of allergenic proteins in simulated gastric fluid.

ABSTRACT:

Background

Safety assessment of genetically modified (GM) food, with regard to allergenic potential of transgene-encoded xenoproteins, typically involves several different methods, evaluation by digestibility being one thereof. However, there are still debates about whether the allergenicity of food allergens is related to their resistance to digestion by the gastric fluid. The disagreements may in part stem from classification of allergens only by their sources, which we believe is inadequate, and the difficulties in achieving identical experimental conditions for studying digestion by simulated gastric fluid (SGF) so that results can be compared. Here, we reclassify allergenic food allergens into alimentary canal-sensitized (ACS) and non-alimentary canal-sensitized (NACS) allerge

SUBMITTER: Jiang B 

PROVIDER: S-EPMC2099448 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature