Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway.

ABSTRACT:

Background

It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream consequences.

Results

Here, we report our analysis of alternative transcripts in the leptin signaling pathway which is responsible for the systemic regulation of macronutrient storage and energy balance. We focused on the circadian expression pattern of a critical component of the leptin signaling system, suppressor of cytokine signaling 3 (SOCS3). On an Affymetrix GeneChip 430A2 microarray, this gene is represented by three probe sets targeting different regions within the 3' end of the last exon. We demonstrate that in murine brown adipose ti

SUBMITTER: Ptitsyn AA 

PROVIDER: S-EPMC2099483 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature