Hitchhiking effects of recurrent beneficial amino acid substitutions in the Drosophila melanogaster genome.

ABSTRACT: Several recent studies have estimated that a large fraction of amino acid divergence between species of Drosophila was fixed by positive selection, using statistical approaches based on the McDonald-Kreitman test. However, little is known about associated selection coefficients of beneficial amino acid mutations. Recurrent selective sweeps associated with adaptive substitutions should leave a characteristic signature in genome variability data that contains information about the frequency and strength of selection. Here, I document a significant negative correlation between the level and the frequency of synonymous site polymorphism and the rate of protein evolution in highly recombining regions of the X chromosome of D. melanogaster. This pattern is predicted by recurrent adaptive protein

SUBMITTER: Andolfatto P 

PROVIDER: S-EPMC2099584 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature