Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes.

ABSTRACT: The newly sequenced genome sequences of 11 Drosophila species provide the first opportunity to investigate variations in evolutionary rates across a clade of closely related species. Protein-coding genes were predicted using established Drosophila melanogaster genes as templates, with recovery rates ranging from 81%-97% depending on species divergence and on genome assembly quality. Orthology and paralogy assignments were shown to be self-consistent among the different Drosophila species and to be consistent with regions of conserved gene order (synteny blocks). Next, we investigated the rates of diversification among these species' gene repertoires with respect to amino acid substitutions and to gene duplications. Constraints on amino acid sequences appear to have been most pronounced on

SUBMITTER: Heger A 

PROVIDER: S-EPMC2099592 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature