Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.

ABSTRACT: Exposure of mammalian cells to ionizing radiation (IR) induces a complex array of cellular responses including cell cycle arrest and/or apoptosis. IR-induced G1 arrest has been shown to depend on the presence of the tumor suppressor p53, which acts as a transcriptional activator of several genes. p53 also plays a role in the induction of apoptosis in response to DNA damage, and this pathway can be activated by both transcription-dependent and -independent mechanisms. Here we report the identification of a novel transcript whose expression is induced in response to IR in a p53-dependent manner, and that shows homology to the type 2C protein phosphatases. We have named this novel gene, wip1. In vitro, recombinant Wip1 displayed characteristics of a type 2C phosphatase, including Mg2+ depende

SUBMITTER: Fiscella M 

PROVIDER: S-EPMC20998 | biostudies-literature | 1997 Jun

REPOSITORIES: biostudies-literature