Assessment of recent HIV-1 infection by a line immunoassay for HIV-1/2 confirmation.

ABSTRACT:

Background

Knowledge of the number of recent HIV infections is important for epidemiologic surveillance. Over the past decade approaches have been developed to estimate this number by testing HIV-seropositive specimens with assays that discriminate the lower concentration and avidity of HIV antibodies in early infection. We have investigated whether this "recency" information can also be gained from an HIV confirmatory assay.

Methods and findings

The ability of a line immunoassay (INNO-LIA HIV I/II Score, Innogenetics) to distinguish recent from older HIV-1 infection was evaluated in comparison with the Calypte HIV-1 BED Incidence enzyme immunoassay (BED-EIA). Both tests were conducted prospectively in all HIV infections newly diagnosed in Switzerland from July 2005 to June

SUBMITTER: Schupbach J 

PROVIDER: S-EPMC2100138 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature