Ontology highlight
ABSTRACT:
SUBMITTER: Lee BH
PROVIDER: S-EPMC2104473 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Cancer cell 20071001 4
Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent ste ...[more]