Antibiotic treatment and factors influencing short and long term outcomes of acute exacerbations of chronic bronchitis.

ABSTRACT:

Background

The MOSAIC study compared moxifloxacin with three standard antibiotic regimens in patients with Anthonisen type 1 acute exacerbations of chronic bronchitis (AECB). Further exploratory analyses were performed to identify prognostic factors of short and long term clinical outcomes and their value for clinical research.

Methods

Outpatients aged > or =45 years were screened between AECB episodes, randomised to treatment upon presenting with an AECB, assessed 7-10 days after study treatment, and followed monthly until a new AECB or for up to 9 months. Logistic regression assessed the predictive factors for clinical cure (return to pre-AECB status) and clinical success (cure or improvement), and a stepwise Cox regression model time to a composite event (failure of study

SUBMITTER: Wilson R 

PROVIDER: S-EPMC2104610 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature