Significant linkage to chromosome 12q24.32-q24.33 and identification of SFRS8 as a possible asthma susceptibility gene.

ABSTRACT:

Background

Asthma is a complex genetic disorder. Many studies have suggested that chromosome 12q harbours a susceptibility gene for asthma and atopy. Linkage on chromosome 12q24.21-q24.33 was investigated in 167 Danish families with asthma.

Methods

A two step procedure was used: (1) a genome-wide scan in one set of families followed by (2) fine scale mapping in an independent set of families in candidate regions with a maximum likelihood score (MLS) of > or =1.5 in the genome-wide scan. Polymorphisms in a candidate gene in the region on 12q24.33 were tested for association with asthma in a family based transmission disequilibrium test.

Results

An MLS of 3.27 was obtained at 12q24.33. The significance of this result was tested by simulation, resulting in a significant

SUBMITTER: Brasch-Andersen C 

PROVIDER: S-EPMC2104763 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature