Ontology highlight
ABSTRACT:
SUBMITTER: Vogt DL
PROVIDER: S-EPMC2111057 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Vogt D L DL Gray C D CD Young W S WS Orellana S A SA Malouf A T AT
Molecular and cellular neurosciences 20070724 3
This report examines the structure and function of ARHGAP4, a novel RhoGAP whose structural features make it ideally suited to regulate the cytoskeletal dynamics that control cell motility and axon outgrowth. Our studies show that ARHGAP4 inhibits the migration of NIH/3T3 cells and the outgrowth of hippocampal axons. ARHGAP4 contains an N-terminal FCH domain, a central GTPase activating (GAP) domain and a C-terminal SH3 domain. Our structure/function analyses show that the FCH domain appears to ...[more]