Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is predominantly the consequence of chronic smoking exposure, but its development may be influenced by genetic variants that affect lung remodelling, inflammation, and defence from oxidant stress. A study was undertaken to determine whether genetic variants within genes encoding the antioxidant enzymes superoxide dismutase (SOD) and catalase may be associated with the development of impaired lung function.

Methods

In a case-control study, the allele and genotype frequencies of functional polymorphisms from SOD1 (CuZnSOD), SOD2 (MnSOD), SOD3 (extracellular SOD), and catalase (CAT) were compared in chronic smokers with normal lung function (resistant smokers) and in those with COPD.

Results

Significantly higher fre

SUBMITTER: Young RP 

PROVIDER: S-EPMC2111196 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature