Clinical significance of anti-GM-CSF antibodies in idiopathic pulmonary alveolar proteinosis.

ABSTRACT:

Background

The role of anti-granulocyte-macrophage colony stimulating factor (GM-CSF) antibodies as a diagnostic marker in idiopathic pulmonary alveolar proteinosis (iPAP) remains unclear.

Methods

Anti-GM-CSF antibodies were detected in blood and bronchoalveolar lavage fluid (BAL) fluid in 13 patients with iPAP. Three patients with secondary PAP, 35 with other pulmonary disorders, and 10 subjects without lung lesions acted as controls. Blood samples only were obtained from 30 healthy medical personnel. Anti-GM-CSF antibodies were detected using immunoblotting and measured semi-quantitatively by serial dilution or concentration methods. The relationship between antibodies and reported severity indicators for iPAP was analysed.

Results

Anti-GM-CSF antibodies could be de

SUBMITTER: Lin FC 

PROVIDER: S-EPMC2111220 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature