Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels.

ABSTRACT:

Background

Nitric oxide is released by immune, epithelial and endothelial cells, and plays an important part in the pathophysiology of asthma.

Objective

To investigate the association of inducible nitric oxide synthases (iNOS) gene repeat polymorphisms with asthma.

Methods

230 families with asthma (842 individuals) were recruited to identify and establish the genetic association of iNOS repeats with asthma and associated phenotypes. Serum nitric oxide levels in selected individuals were measured and correlated with specific genotypes. Multiple logistic regression analysis was performed to determine the effect of age and sex.

Results

A total of four repeats-a (CCTTT)n promoter repeat, a novel intron 2 (GT)n repeat (BV680047), an intron 4 (GT)n repeat (AFM311ZB1)

SUBMITTER: Batra J 

PROVIDER: S-EPMC2111289 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature