A novel gene variation of TNFalpha associated with ankylosing spondylitis: a reconfirmed study.

ABSTRACT:

Background

A great deal of evidence has shown that non-human leucocyte antigen (HLA)-B27 genes may play crucial roles in the aetiology of ankylosing spondylitis (AS), but there is little evidence of a relationship with tumour necrosis factor (TNF)alpha gene variation. One functional single-nucleotide polymorphism (SNP), -850 C-->T, on the TNFalpha gene promoter region was identified and confirmed to be significantly associated with AS by our recent study.

Objective

To investigate whether the -850 C-->T SNP is a susceptibility locus for AS or is only a marker linked to potential disease gene loci in a Chinese population.

Methods

Ten common SNPs were selected from nine inflammatory genes covering the right and left flanking regions of the TNFalpha gene, which span a reg

SUBMITTER: Zhu X 

PROVIDER: S-EPMC2111619 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature