A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with increasing prevalence and mortality. It is associated with airway obstruction, increased airway hyper-responsiveness (AHR), and ongoing airway and lung inflammation dominated by CD8 lymphocytes and neutrophils. Single-nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) gene have been associated with AHR and COPD.

Objective

To assess whether SNPs in ADAM33 are associated with the severity of AHR and airway inflammation in COPD.

Methods

Eight SNPs in ADAM33 (F+1, Q-1, S_1, S_2, ST+5, T_1, T_2, V_4) were genotyped in 111 patients with COPD (96 males, 69 current smokers, mean (standard deviation (SD)), aged 62 (8) years, median pack-years 42 (IQR 31-55), mea

SUBMITTER: Gosman MM 

PROVIDER: S-EPMC2117167 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature