Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction.

ABSTRACT:

Background

Atopy is considered to be a complex genetic trait and does not follow a simple mendelian pattern of inheritance. It is now well recognised that gene-gene interactions are important in complex genetic disease.

Aim

To analyse the influence of gene-gene interactions in the development of atopy.

Methods

A total of 2055 ethnically identical participants aged 10-18 years living in rural areas on Jeju Island, Korea, were randomly recruited. Atopy was defined as a positive skin prick test response to one or more common inhalant allergens. Gene-gene interactions among 12 polymorphic loci were analysed in the seven candidate genes of atopy using the multidimensionality-reduction method.

Results

A significant interaction was found between V297I in the gene codi

SUBMITTER: Park HW 

PROVIDER: S-EPMC2117169 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature