Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma.

ABSTRACT:

Background

Epidemiological evidence from observational studies has suggested that blood levels and dietary intake of selenium of adults with asthma are lower than those of controls. The only previous trial of selenium supplementation in adults with asthma found no objective evidence of benefit but involved only 24 participants.

Methods

A randomised, double blind, placebo-controlled trial of selenium supplementation was performed in adults with asthma in London, UK, the majority of whom (75%) reported inhaled steroid use at baseline. 197 participants were randomised to receive either a high-selenium yeast preparation (100 microg daily, n=99) or placebo (yeast only, n=98) for 24 weeks. The primary outcome was asthma-related quality of life (QoL) score. Secondary outcomes inclu

SUBMITTER: Shaheen SO 

PROVIDER: S-EPMC2117223 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature