Role of the renin-angiotensin system in ventilator-induced lung injury: an in vivo study in a rat model.

ABSTRACT:

Background

Injurious mechanical ventilation can cause a pro-inflammatory reaction in the lungs. Recent evidence suggests an association of the renin-angiotensin system (RAS) with lung inflammation. A study was undertaken to investigate the pathogenic role of the RAS in ventilator-induced lung injury (VILI) and to determine whether VILI can be attenuated by angiotensin converting enzyme (ACE) inhibition.

Methods

Male Sprague-Dawley rats were mechanically ventilated for 4 h with low (7 ml/kg) or high (40 ml/kg) tidal volumes; non-ventilated rats were used as controls. Lung injury and inflammation were measured by the lung injury score, protein leakage, myeloperoxidase activity, pro-inflammatory cytokine levels and nuclear factor (NF)-kappaB activity. Expression of the RAS comp

SUBMITTER: Jerng JS 

PROVIDER: S-EPMC2117227 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature