Profiling serum biomarkers in patients with COPD: associations with clinical parameters.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease associated with significant systemic consequences. Recognition of the systemic manifestations has stimulated interest in identifying circulating biomarkers in these patients. A systematic analysis was undertaken of multiple protein analytes in the serum of well characterised patients with COPD and matched controls using novel protein microarray platform (PMP) technology.

Methods

Forty-eight patients (65% men) with COPD (forced expiratory volume in 1 s <55%) and 48 matched controls were studied. Anthropometric parameters, pulmonary function tests, 6-minute walk distance, the BODE index and the number of exacerbations were measured and the association of these outcomes with the baseline lev

SUBMITTER: Pinto-Plata V 

PROVIDER: S-EPMC2117244 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature