A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry.

ABSTRACT:

Background

Dementia is common in Parkinson's disease, but the underlying brain pathology is not yet fully understood.

Aim

To examine the changes in the brain of patients with Parkinson's disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging.

Methods

Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson's disease and dementia (PDD; n = 16) and Parkinson's disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used.

Results

Widespread areas of cortical atrophy were found in patients wit

SUBMITTER: Beyer MK 

PROVIDER: S-EPMC2117633 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature