Ontology highlight
ABSTRACT:
SUBMITTER: Chan JR
PROVIDER: S-EPMC2118145 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20061030 12
Aberrant cytokine expression has been proposed as an underlying cause of psoriasis, although it is unclear which cytokines play critical roles. Interleukin (IL)-23 is expressed in human psoriasis and may be a master regulator cytokine. Direct intradermal administration of IL-23 in mouse skin, but not IL-12, initiates a tumor necrosis factor-dependent, but IL-17A-independent, cascade of events resulting in erythema, mixed dermal infiltrate, and epidermal hyperplasia associated with parakeratosis. ...[more]