Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine.

ABSTRACT: Dissemination of Yersinia pseudotuberculosis within mice after oral inoculation was analyzed. Y. pseudotuberculosis translocated to organs such as the liver and spleen shortly after oral inoculation, but was quickly cleared. In contrast, a second temporally distinct bacterial translocation event resulted in successful hepatosplenic replication of the bacteria. Replicating pools of bacteria could be established in these organs in mouse mutants that lacked Peyer's patches. These animals frequently had sterile mesenteric lymph nodes, a finding consistent with translocation taking place independently of regional lymph node colonization. In further contradiction to accepted models for dissemination of enteropathogens, clonal analysis revealed that bacteria causing disease in the spleen and live

SUBMITTER: Barnes PD 

PROVIDER: S-EPMC2118325 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature