Ontology highlight
ABSTRACT:
SUBMITTER: Serafini M
PROVIDER: S-EPMC2118428 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20070116 1
For decades, in vitro expansion of transplantable hematopoietic stem cells (HSCs) has been an elusive goal. Here, we demonstrate that multipotent adult progenitor cells (MAPCs), isolated from green fluorescent protein (GFP)-transgenic mice and expanded in vitro for >40-80 population doublings, are capable of multilineage hematopoietic engraftment of immunodeficient mice. Among MAPC-derived GFP+CD45.2+ cells in the bone marrow of engrafted mice, HSCs were present that could radioprotect and recon ...[more]