Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo.

ABSTRACT: Dendritic cell (DC) activation is a prerequisite for T cell priming. During infection, activation can ensue from signaling via pattern-recognition receptors after contact with pathogens or infected cells. Alternatively, it has been proposed that DCs can be activated indirectly by signals produced by infected tissues. To address the contribution of tissue-derived signals, we measured DC activation in a model in which radioresistant cells can or cannot respond to lipopolysaccharide (LPS). We report that recognition of LPS by the radioresistant compartment is sufficient to induce local and systemic inflammation characterized by high circulating levels of tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta, IL-6, and CC chemokine ligand 2. However, this is not sufficient to activate DCs,

SUBMITTER: Nolte MA 

PROVIDER: S-EPMC2118612 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature