Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese population.

ABSTRACT:

Background

Nasopharyngeal carcinoma is endemic in Southern China, displays a strong relationship with genetic susceptibility and associates with Epstein-Barr virus infection. Toll-like receptor 3 (TLR3) plays an important role in the antivirus response. Therefore, we examined the association between TLR3 gene polymorphisms and NPC susceptibility.

Methods

We performed a case-control study of 434 NPC cases and 512 healthy controls matched on age, sex and residence. Both cases and controls are of Cantonese origin from Southern China. Genetic variants in TLR3 were determined by polymerase chain reaction (PCR)-based DNA direct sequencing and four SNPs were genotyped in all samples.

Results

Our results showed that allele C for SNP 829A/C increased NPC risk significantly ((p

SUBMITTER: He JF 

PROVIDER: S-EPMC2121103 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature