Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE).

ABSTRACT: Despite the widespread use of chemotherapy and other control strategies over the past 50years, transmission rates for schistosomiasis have changed little. Regardless of the approach used, future control efforts will require a more complete understanding of fundamental parasite biology. Schistosomes undergo complex development involving an alteration of parasite generations within a mammalian and freshwater molluscan host in the completion of its lifecycle. Little is known about factors controlling schistosome development, but understanding these processes may facilitate the discovery of new control methods. Therefore, our goal in this study is to determine global developmentally regulated and stage-specific gene expression in Schistosoma mansoni using serial analysis of gene expression (SA

SUBMITTER: Williams DL 

PROVIDER: S-EPMC2121609 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature