3DNA: a software package for the analysis, rebuilding and visualization of three-dimensional nucleic acid structures.

ABSTRACT: We present a comprehensive software package, 3DNA, for the analysis, reconstruction and visualization of three-dimensional nucleic acid structures. Starting from a coordinate file in Protein Data Bank (PDB) format, 3DNA can handle antiparallel and parallel double helices, single-stranded structures, triplexes, quadruplexes and other complex tertiary folding motifs found in both DNA and RNA structures. The analysis routines identify and categorize all base interactions and classify the double helical character of appropriate base pair steps. The program makes use of a recently recommended reference frame for the description of nucleic acid base pair geometry and a rigorous matrix-based scheme to calculate local conformational parameters and rebuild the structure from these parameters. The r

SUBMITTER: Lu XJ 

PROVIDER: S-EPMC212791 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature